HiTOP - Using the HiTOP to Accelerate Clinical Neuroscience (1.5 CEs)

Abstract

Despite massive funding, progress in identifying robust neural correlates of mental illness, to say nothing of biomarkers that might be used in diagnosis, has been painfully slow. Understanding the neurobiological systems involved in psychopathology has been hindered by the limitations of categorical nosologies, spurring the development of alternative dimensional systems for characterizing psychopathology. HiTOP provides more promising targets for clinical neuroscience than traditional diagnostic categories and can facilitate cumulative integration of existing research. In this symposium, we showcase the use of HiTOP to accelerate clinical neuroscience. The first talk (DeYoung) describes a systematic review of large neuroimaging studies that used dimensional measures of psychopathology locatable within HiTOP. The second talk (Kaczkurkin) describes a study using the very large ABCD sample to identify neural correlates of internalizing symptom dimensions at multiple levels of HiTOP simultaneously. The third talk (Nusslock) describes a program of research using dimensional models of psychopathology to understand the role of inflammation in the neurobiological sequelae of early life adversity. Lastly, the discussant (Martin) will present commentary and moderate discussion with the audience about prospects for HiTOP in clinical neuroscience. There will also be time for a couple of questions in between talks.

Discussant

Lizz Martin | University of California, Irvine