Building from the ground up - Symptom-focused approaches to uncover the hierarchical structure

Abstract

The maturation of clinical psychology as a replicable and clinically translatable science is contingent upon our ability to conceptualize and model psychopathology in ways that reflect the nuances of these systems in isolation and in relation to risk and resilience factors of interest. Dr. Miri Forbes will start the symposium presenting a data-driven hierarchical re-organization of DSM-5 symptoms across 14,763 individuals, highlighting areas of similarity vs. divergence from the current HiTOP model. Dr. Jeffrey Girard will then present work comparing several different hierarchical latent variable modeling options for affective and psychotic symptoms in a sample of 1,042 patients hospitalized for acute psychosis. Dr. Daniel Moriarity will illustrate how moderated non-linear factor analysis is an apt technique for identifying hierarchical phenotypes associated with a risk/resilience factor, using the inflammatory phenotyping of depression across 3 samples and 1,974 adults as a use-case. Dr. Holly Levin-Aspenson will present work illustrating the hierarchical structure of symptom data (including uncommon data on gambling and eating pathology) in 7,403 adults and identification of which levels of psychopathology best explain differences in psychosocial functioning. Finally, Dr. Keanan Joyner will make concluding remarks, summarizing key points for the talks, highlighting their relevance to HiTOP’s mission, and facilitate questions

Discussant

Keanan Joyner | University of California, Berkeley